Memorial Hospital Research Laboratories

The Ricardo Otazo Lab

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Research

Ricardo Otazo
Ricardo Otazo, PhD
Vice-Chair for Research, Chief of MRI Physics; Member in Medical Physics and Radiology

The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion resistant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models.

The lab develops novel magnetic resonance imaging (MRI) techniques to increase imaging speed, improve motion tolerance, image physical tissue parameters, and guide radiotherapy in real-time using advances in MRI acquisition (pulse sequences) and image reconstruction algorithms. Highlights include:

  • Non-Cartesian k-space acquisitions for motion-resistant and motion navigated imaging
  • Deep learning reconstruction of undersampled k-space data for fast 3D and 4D MRI
  • Real-time 4D MRI for radiotherapy guidance
  • Fast motion-resistant pediatric MRI with reduced anesthesia
  • Deep learning quantification of dynamic contrast-enhanced MRI
  • High-resolution distortion-free diffusion MRI in the body
  • Fast motion-resistant T1-rho mapping

Research Projects

The Ricardo Otazo Lab

Publications

Feng L, Block KT, Grimm R, Chandarana H, Kim S, Xu J, Axel L, Sodickson DK, Otazo R. Golden-Angle Radial Sparse Parallel MRI: Combination of compressed sensing, parallel imaging and golden-angle radial sampling for fast and flexible dynamic volumetric MRI. Magn Reson Med. 2014 Sep;72(3):707-17 https://pubmed.ncbi.nlm.nih.gov/24142845/

Otazo R, Candès E, Sodickson DK. Low-rank plus sparse matrix decomposition for accelerated dynamic MRI with separation of background and dynamic components. Magn Reson Med. 2015 Mar;73(3):1125-36. https://pubmed.ncbi.nlm.nih.gov/24760724/

Feng L, Tyagi N, Otazo R. MRSIGMA: Magnetic Resonance SIGnature MAtching for real-time volumetric imaging. Magn Reson Med. 2020 Sep;84(3):1280-1292. Epub 2020 Feb 21 https://pubmed.ncbi.nlm.nih.gov/32086858/

Jafari R, Do RKG, LaGratta MD, Fung M, Bayram E, Cashen T, Otazo R. GRASPNET: Fast spatiotemporal deep learning reconstruction of golden-angle radial data for free-breathing dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed. 2023 Mar;36(3):e4861. Epub 2022 Nov 25 https://pubmed.ncbi.nlm.nih.gov/36305619/

Wu C, Krishnamoorthy G, Yu V, Subashi E, Rimner A, Otazo R. 4D lung MRI with high-isotropic-resolution using half-spoke (UTE) and full-spoke 3D radial acquisition and temporal compressed sensing reconstruction.  Phys Med Biol. 2023 Jan 27;68(3). https://pubmed.ncbi.nlm.nih.gov/36535035/

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People

Ricardo Otazo

Ricardo Otazo, PhD

Vice-Chair for Research, Chief of MRI Physics; Member in Medical Physics and Radiology

  • The Ricardo Otazo lab develops novel magnetic resonance imaging (MRI) techniques for cancer applications including fast imaging, motion resistant imaging, quantitative imaging of physical tissue parameters, and real-time MRI-guided radiotherapy using advances in MRI acquisition and computational models.
[email protected]
Email Address

Members

Or Alus

Research Associate

Juntong Jing

Graduate Student

Anthony Mekhanik

MRI Engineer

Anna Miranda

Administrative Assistant

Victor Murray

Senior Research Scientist

Joel Jose (JJ) Nario

Graduate Student

Saad Siddiq

Research Technician

Sandeep Yogi

Research Fellow

Mark T. Burgess

Collaborator, Assistant Member

Ouri Cohen

Collaborator, Assistant Member

Youngwook Kee

Collaborator, Assistant Member

Can Wu

Collaborator, Assistant Member

Lab Affiliations

Achievements

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