Memorial Hospital Research Laboratories

The Jian Carrot-Zhang Lab

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Research

Jian Carrot-Zhang
Jian Carrot-Zhang, PhD
GSK Faculty Member

The Carrot-Zhang Lab started in 2022. We focus on developing cutting-edge computational methods to link the germline genome to the specific somatic phenotypes, in order to better characterize cancer risk and response to treatment mechanisms. Another focus of the lab is combining statistical modeling and large-scale, multiethnic clinical genomic cohorts to understand how cancer is impacted by genetic ancestry, with the goal of improving precision oncology for all. The group is also involved in Project GENIE (Genomics Evidence Neoplasia Information Exchange), a collaboration with The Cancer Genome Atlas (TCGA) and the American Association for Cancer Research (AACR), and has a strong interest in discovering new cancer drivers through whole-genome sequencing. More information about our research is available here.

Publications

Nassar AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J, Gusev A. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. Cancer Cell. 2022 Oct 10;40(10):1161-1172.e5. doi: 10.1016/j.ccell.2022.08.022. Epub 2022 Sep 29. PMID: 36179682; PMCID: PMC9559771.

Carrot-Zhang J, Han S, Zhou W, Damrauer JS, Kemal A; Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R. Analytical protocol to identify local ancestry-associated molecular features in cancer. STAR Protoc. 2021 Sep 20;2(4):100766. doi: 10.1016/j.xpro.2021.100766. PMID: 34585150; PMCID: PMC8456058.

Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M. Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations. Cancer Discov. 2021 Mar;11(3):591-598. doi: 10.1158/2159-8290.CD-20-1165. Epub 2020 Dec 2. PMID: 33268447; PMCID: PMC7933062.

Carrot-Zhang J, et al., Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R.Comprehensive Analysis of Genetic Ancestry and its molecular correlates in cancer. Cancer Cell 2020; 37 (5) 639-654.

Carrot-Zhang J, et al. Meyerson M, Govindan R, Imielinski M.  Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway Cell Rep. 2021 Feb 2;34(5):108707. doi: 10.1016/j.celrep.2021.108707.

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People

Jian Carrot-Zhang

Jian Carrot-Zhang, PhD

GSK Faculty Member

  • Computational Geneticist focused on germline-somatic interaction in multi-ethnic populations.
  • Postdoc: Dana-Farber Cancer Institute and Broad Institute
  • PhD, McGill University
  • Instructor, Harvard Medical School

Members

David Ma
David Ma

Computational Biologist I

Hussein Mohsen

Postdoctoral Research Fellow

Tomin Perea-Chamblee
Tomin Perea-Chamblee

Bioinformatics Software Engineer

Genesis Pineda
Genesis Pineda

Administrative Assistant

Lab Affiliations

Achievements

  • National Cancer Institute – K99 Pathway to Independence Award, “Understanding ancestral contribution to lung adenocarcinoma.” (Role: PI) (2021)
  • Banting Postdoctoral Fellowships Award, Canadian Institutes of Health Research (2019)