Human Oncology & Pathogenesis Program

The Asmin Tulpule Lab

Asmin Tulpule, MD, PhD

Physician-scientist

The Tulpule Lab is interested in a long-standing question in cell biology: how do cells organize and compartmentalize critical cellular processes within the crowded and heterogeneous intracellular space? We focus on an emerging set of self-assembling, protein-based structures known as biomolecular condensates and their role in cancer, including a newly discovered pathogenic condensate – membraneless receptor tyrosine kinase (RTK) protein granules. Through interdisciplinary approaches combining cancer signaling, structural biology, biophysics, and high-resolution microscopy, we hope to understand how the compartmentalization of oncogenic fusion proteins can both co-opt and disrupt cellular condensates in order to drive cancer.

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Publications

Menon S, Breese MR, Lin YP, Allegakoen HP, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Trever G. Bivona#, Asmin Tulpule #. FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. bioRxiv 2023.04.30.538578; doi: https://doi.org/10.1101/2023.04.30.538578.

Gonzalez-Martinez D, Roth L, Mumford TR, Guan J, Huang B, Tulpule A, Bivona TG, Bugaj LJ. Oncogenic protein condensates suppress growth factor perception and modulate drug tolerance. Biorxiv. doi: https://doi.org/10.1101/2022.02.02.478845

Tulpule, A*., J. Guan*, D. S. Neel*, H. R. Allegakoen, Y. P. Lin, D. Brown, Y. T. Chou, A. Heslin, N. Chatterjee, S. Perati, S. Menon, T. A. Nguyen, J. Debnath, A. D. Ramirez, X. Shi, B. Yang, S. Feng, S. Makhija, B. Huang^#and T. G. Bivona^# (2021). “Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.” Cell. 2021 May 13;184(10):2649-2664.

Chatterjee, N. E. Pazarentzos, M. K. Mayekar, P. Gui, D. V. Allegakoen, G. Hrustanovic, V. Olivas, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, T. Ideker, W. Wu, J. Suzuki, B. A. Barad, Y. Kirichok, J. S. Fraser, W. A. Weiss, N. J. Krogan, A. Tulpule, A. J. Sabnis and T. G. Bivona (2019). “Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.” Cell Rep 28(9): 2317-2330.

Tulpule, A., J. M. Kelley, M. W. Lensch, J. McPherson, I. H. Park, O. Hartung, T. Nakamura, T. M. Schlaeger, A. Shimamura and G. Q. Daley (2013). “Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction.” Cell Stem Cell 12(6): 727-736.

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People

Asmin Tulpule, MD, PhD

Physician-scientist

The Tulpule lab studies how cells compartmentalize critical cellular processes with a focus on biomolecular condensates in cancer.
MD, Harvard Medical School
PhD, Harvard University